Issue 30, 2019

A facile approach to 2-alkoxyindolin-3-one and its application to the synthesis of N-benzyl matemone

Abstract

2-Alkoxycarbonylindolin-3-one is synthesized from a methoxyglycine derivative via a 1,2-aza-Brook rearrangement followed by cyclization with bis(trimethylsilyl)aluminum chloride. A short-step synthesis of N-benzyl matemone is successfully carried out using the present indolin-3-one synthesis.

Graphical abstract: A facile approach to 2-alkoxyindolin-3-one and its application to the synthesis of N-benzyl matemone

Supplementary files

Article information

Article type
Paper
Submitted
21 Mar 2019
Accepted
27 May 2019
First published
03 Jun 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 17341-17346

A facile approach to 2-alkoxyindolin-3-one and its application to the synthesis of N-benzyl matemone

M. Shimizu, H. Imazato, I. Mizota and Y. Zhu, RSC Adv., 2019, 9, 17341 DOI: 10.1039/C9RA02204J

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