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Issue 19, 2019
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Antibacterial activity and mechanism of action of a thiophenyl substituted pyrimidine derivative

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Abstract

The issue of multidrug resistant bacteria is a worldwide health threat. To develop new antibacterial agents with new mechanisms of action is thus an urgent request to address this antibiotic resistance crisis. In the present study, a new thiophenyl-pyrimidine derivative was prepared and utilized as an effective antibacterial agent against Gram-positive strains. In the tests against MRSA and VREs, the compound showed higher antibacterial potency than that of vancomycin and methicillin. The mode of action is probably attributed to the effective inhibition of FtsZ polymerization, GTPase activity, and bacterial cell division, which cause bactericidal effects. The compound could be a potential candidate for further development as an effective antibiotic to combat drug-resistant bacteria.

Graphical abstract: Antibacterial activity and mechanism of action of a thiophenyl substituted pyrimidine derivative

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Supplementary files

Article information


Submitted
07 Feb 2019
Accepted
02 Apr 2019
First published
05 Apr 2019

This article is Open Access

RSC Adv., 2019,9, 10739-10744
Article type
Paper

Antibacterial activity and mechanism of action of a thiophenyl substituted pyrimidine derivative

Z. Fang, Y. Li, Y. Zheng, X. Li, Y. Lu, S. Yan, W. Wong, K. Chan, K. Wong and N. Sun, RSC Adv., 2019, 9, 10739
DOI: 10.1039/C9RA01001G

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