Issue 15, 2019

Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology

Abstract

We report a new synthetic route to a series of α-carboxynitrobenzyl photocaged L-aspartates for application in time-resolved structural biology. The resulting compounds were characterised in terms of UV/Vis absorption properties, aqueous solubility and stability, and photocleavage rates (τ = μs to ms) and quantum yields (φ = 0.05 to 0.14).

Graphical abstract: Synthesis and characterisation of α-carboxynitrobenzyl photocaged l-aspartates for applications in time-resolved structural biology

Supplementary files

Article information

Article type
Paper
Submitted
05 Feb 2019
Accepted
06 Mar 2019
First published
15 Mar 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 8695-8699

Synthesis and characterisation of α-carboxynitrobenzyl photocaged L-aspartates for applications in time-resolved structural biology

J. I. Zaitseva-Kinneberg, A. Puchert, Y. Pfeifer, H. Yan, B. A. Yorke, H. M. Müller-Werkmeister, C. Uetrecht, J. Rehbein, N. Huse, A. R. Pearson and M. Sans, RSC Adv., 2019, 9, 8695 DOI: 10.1039/C9RA00968J

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