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Issue 15, 2019
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Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers

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Abstract

A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared via microwave heating and assayed for their anti-mycobacterial activities. The compound with a butyl chain as a spacer between the two pharmacophores and piperidine as the secondary amine component on the isoindoline ring was the most potent and non-cytotoxic among the synthesized compounds, exhibiting a minimum inhibitory concentration (MIC99) of 6.25 μg mL−1 against Mycobacterium tuberculosis.

Graphical abstract: Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers

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Supplementary files

Article information


Submitted
24 Dec 2018
Accepted
03 Mar 2019
First published
13 Mar 2019

This article is Open Access

RSC Adv., 2019,9, 8515-8528
Article type
Paper

Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers

A. Rani, A. Viljoen, M. D. Johansen, L. Kremer and V. Kumar, RSC Adv., 2019, 9, 8515
DOI: 10.1039/C8RA10532D

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