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Rhodium(iii)-catalyzed [3 + 3] annulation reactions of N-nitrosoanilines and cyclopropenones: an approach to functionalized 4-quinolones

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Abstract

We report Rh(III)-catalyzed [3 + 3] annulation reactions for the preparation of functionalized 4-quinolones from N-nitrosoanilines and cyclopropenones. This reaction allows C–C bond cleavage and the construction of C–C and C–N bonds via N-nitroso-directed C–H activation. Good regioselectivity is achieved by using unsymmetrical meta-substituted N-nitrosoanilines. With this method, a variety of 4-quinolone derivatives were prepared in moderate to good yields under mild conditions.

Graphical abstract: Rhodium(iii)-catalyzed [3 + 3] annulation reactions of N-nitrosoanilines and cyclopropenones: an approach to functionalized 4-quinolones

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Publication details

The article was received on 12 Oct 2019, accepted on 31 Oct 2019 and first published on 01 Nov 2019


Article type: Research Article
DOI: 10.1039/C9QO01250H
Org. Chem. Front., 2019, Advance Article

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    Rhodium(III)-catalyzed [3 + 3] annulation reactions of N-nitrosoanilines and cyclopropenones: an approach to functionalized 4-quinolones

    Y. Liu, Y. Tian, K. Su, P. Wang, X. Guo and B. Chen, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO01250H

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