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Visible-light-mediated de-aminative alkylation of N-arylamines with alkyl Katritzky salts

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Abstract

A visible-light-mediated de-aminative alkylation of N-arylamines has been developed, providing direct access to α-amino C–H functionalization from readily available Katritzky salts under mild conditions. In some cases, this operationally simple protocol can be performed in the absence of a photocatalyst. A wide range of substrates and functional groups are tolerated. The utility of this approach is highlighted by its application to the late-state modification of drug molecules, natural products and peptides.

Graphical abstract: Visible-light-mediated de-aminative alkylation of N-arylamines with alkyl Katritzky salts

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Publication details

The article was received on 24 Sep 2019, accepted on 18 Oct 2019 and first published on 22 Oct 2019


Article type: Research Article
DOI: 10.1039/C9QO01175G
Org. Chem. Front., 2019, Advance Article

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    Visible-light-mediated de-aminative alkylation of N-arylamines with alkyl Katritzky salts

    Y. Xu, Z. Xu, Z. Liu and H. Lou, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO01175G

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