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K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with ammonium thiocyanate at room temperature

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Abstract

A facile and efficient approach for the direct thiocyanation of pyrazolin-5-ones via a radical mechanism has been established for the first time. A series of 4-thiocyanated 5-hydroxy-1H-pyrazoles were synthesized in fair to good yields by K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with NH4SCN at room temperature under simple and mild reaction conditions with atom- and step-economy and good functional group tolerance.

Graphical abstract: K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with ammonium thiocyanate at room temperature

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Publication details

The article was received on 24 Sep 2019, accepted on 30 Nov 2019 and first published on 03 Dec 2019


Article type: Research Article
DOI: 10.1039/C9QO01174A
Org. Chem. Front., 2020, Advance Article

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    K2S2O8-promoted direct thiocyanation of pyrazolin-5-ones with ammonium thiocyanate at room temperature

    X. Mao, J. Ni, B. Xu and C. Ding, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01174A

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