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Trifluoroacetimidoyl Halide: A Potent Synthetic Origin

Abstract

The preparation of fluoro-containing compounds has attracted considerable attention due to the important applications of its related chemicals. Among the candidates, trifluoroacetimidoyl halides are considered as potent trifluoromethyl synthons to construct a wide variety of trifluoromethyl-containing compounds and trifluoromethyl-substituted N-heterocycles, which have found extensive applications in the fields of organic synthesis, pharmaceuticals, agrochemicals, and materials science. In the review, the recent advances regarding the synthetic applications of trifluoroacetimidoyl halides have been summarized. We have specially focused on two different reaction modes upon trifluoroacetimidoyl halides, including coupling and annulation reaction, to illustrate their synthetic applications and potentials in the construction of valuable trifluoromethyl-containing molecules. Their preparations have been covered as well.

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Publication details

The article was received on 22 Sep 2019, accepted on 29 Nov 2019 and first published on 02 Dec 2019


Article type: Review Article
DOI: 10.1039/C9QO01167F
Org. Chem. Front., 2019, Accepted Manuscript

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    Trifluoroacetimidoyl Halide: A Potent Synthetic Origin

    X. Wu, S. hu and Z. Chen, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QO01167F

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