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Pd-Catalyzed multicomponent reaction of sulfonyl azides, primary amines and methyl α-isocyanoacetates: highly efficient synthesis of tetrasubstituted imidazolone derivatives

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Abstract

A highly efficient Pd-catalyzed multicomponent reaction of sulfonyl azides, primary amines and methyl α-isocyanoacetates was developed. This method provided an efficient and simple strategy for the synthesis of tetrasubstituted imidazolone derivatives in good to excellent yields via sulfonyl guanidine intermediates. This protocol shows a broad substrate scope and mild reaction conditions, and new C–C, and C–N bonds were constructed via a three-component reaction in one step.

Graphical abstract: Pd-Catalyzed multicomponent reaction of sulfonyl azides, primary amines and methyl α-isocyanoacetates: highly efficient synthesis of tetrasubstituted imidazolone derivatives

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The article was received on 10 Sep 2019, accepted on 27 Sep 2019 and first published on 30 Sep 2019


Article type: Research Article
DOI: 10.1039/C9QO01122F
Org. Chem. Front., 2019, Advance Article

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    Pd-Catalyzed multicomponent reaction of sulfonyl azides, primary amines and methyl α-isocyanoacetates: highly efficient synthesis of tetrasubstituted imidazolone derivatives

    F. Wang, P. Xu, B. Liu, S. Wang and S. Ji, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO01122F

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