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Rhodium-catalyzed biheteroaryl-2-carbonitrile synthesis via double C–H activation

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Abstract

Rhodium(III)-catalyzed double C–H activation and in situ dealcoholization to generate useful biheteroaryl-2-carbonitriles have been well developed via a CDC mechanism, in which benzimidates act as both directing groups and the precursors of nitrile groups. This simple and atom-economical method synthesizes various biheteroaryl-2-carbonitrile derivatives, which could be further transformed to more complex compounds.

Graphical abstract: Rhodium-catalyzed biheteroaryl-2-carbonitrile synthesis via double C–H activation

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Publication details

The article was received on 09 Sep 2019, accepted on 16 Oct 2019 and first published on 16 Oct 2019


Article type: Research Article
DOI: 10.1039/C9QO01114E
Org. Chem. Front., 2019, Advance Article

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    Rhodium-catalyzed biheteroaryl-2-carbonitrile synthesis via double C–H activation

    H. Xu, Y. Zhu, J. Yang, X. Chai and L. Dong, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO01114E

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