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Access to polyfunctionalized carbazoles through π-extension of 2-methyl-3-oxoacetate indoles

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Abstract

Formal [4 + 2] annulation of 2-methyl-3-oxoacetate indoles with naphthalene-1,4-dione and dialkyl acetylene dicarboxylates has been successfully developed. A structurally diverse set of polyfunctionalized carbazoles was efficiently synthesized in acceptable to excellent yields. This reaction features H2O as the only by-product, has a broad substrate scope and proceeds under mild conditions.

Graphical abstract: Access to polyfunctionalized carbazoles through π-extension of 2-methyl-3-oxoacetate indoles

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Publication details

The article was received on 05 Sep 2019, accepted on 26 Sep 2019 and first published on 27 Sep 2019


Article type: Research Article
DOI: 10.1039/C9QO01093A
Org. Chem. Front., 2019, Advance Article

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    Access to polyfunctionalized carbazoles through π-extension of 2-methyl-3-oxoacetate indoles

    Y. Guo, Z. Wang, Y. Zhu, Q. Zhang, D. Wei, X. Liu and Z. Fu, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO01093A

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