Jump to main content
Jump to site search


Polyoxygenated meroterpenoids and a bioactive illudalane derivative from a co-culture of Armillaria sp. and Epicoccum sp.

Author affiliations

Abstract

Three novel polyoxygenated meroterpenoids, epiterenoids A–C (1–3), and a new illudalane derivative, armiloid A (4), were isolated from a liquid co-culture of Armillaria sp. and the endophytic fungus Epicoccum sp. YUD17002 associated with Gastrodia elata. Their structures were established by extensive spectroscopic analyses, X-ray crystal diffraction, and TDDFT-ECD calculations. Compounds 1–3 possessed a 5/6/4/5/5-fused pentacyclic ring scaffold. Plausible biosynthetic pathways for 1–4 are proposed. Compound 4 exhibited potent AChE inhibitory activity, with an IC50 value of 4.91 μM.

Graphical abstract: Polyoxygenated meroterpenoids and a bioactive illudalane derivative from a co-culture of Armillaria sp. and Epicoccum sp.

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Sep 2019, accepted on 08 Oct 2019 and first published on 14 Oct 2019


Article type: Research Article
DOI: 10.1039/C9QO01087D
Org. Chem. Front., 2019, Advance Article

  •   Request permissions

    Polyoxygenated meroterpenoids and a bioactive illudalane derivative from a co-culture of Armillaria sp. and Epicoccum sp.

    H. Li, L. Tang, T. Liu, R. Yang, Y. Yang, H. Zhou and Z. Ding, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO01087D

Search articles by author

Spotlight

Advertisements