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Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition

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Abstract

Commiphorines A (1), an unprecedented sesquiterpenoid heterodimer featuring a 5/7(5)/4/10/5 ring system, and B (2), a dimeric sesquiterpenoid possessing an unusual 1,4-dioxin motif and a 6/6/5/6/6/6 polycyclic system, and two intermediates 3 and 4 were isolated from Resina Commiphora. A plausible biosynthetic route for 1 and 2 was proposed. Compound 2 could significantly suppress LPS-induced inflammation through NF-κB and MAPK signaling pathways in mouse peritoneal macrophages. Compounds 1 and 2 could inhibit lipid synthesis in HepG2 cells.

Graphical abstract: Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition

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Publication details

The article was received on 24 Aug 2019, accepted on 07 Oct 2019 and first published on 09 Oct 2019


Article type: Research Article
DOI: 10.1039/C9QO01046G
Org. Chem. Front., 2019, Advance Article

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    Commiphorines A and B, unprecedented sesquiterpenoid dimers from Resina Commiphora with striking activities on anti-inflammation and lipogenesis inhibition

    L. Dong, D. Qin, Q. Di, Y. Liu, W. Chen, S. Wang and Y. Cheng, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO01046G

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