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Transition Metal-Free Aerobic Oxidative Cleavage of C−N Bonds of α-Amino Esters

Abstract

An efficient transition metal-free cleavage of C−N bonds of α-amino esters under mild conditions has been developed. The reaction was performed in the presence of KOtBu and molecular oxygen. Mechanistic studies reveal that the reaction proceeds through a base-mediated aerobic oxidative cleavage pathway involving the formation of a hydroperoxide intermediate.

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Publication details

The article was received on 21 Aug 2019, accepted on 10 Oct 2019 and first published on 12 Oct 2019


Article type: Research Article
DOI: 10.1039/C9QO01033E
Org. Chem. Front., 2019, Accepted Manuscript

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    Transition Metal-Free Aerobic Oxidative Cleavage of C−N Bonds of α-Amino Esters

    S. Tan, F. Li, S. Park and S. Kim, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QO01033E

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