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Cu-Catalysed carboxylation of aryl boronic acids with CO2

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Abstract

A copper/N-heterocyclic carbene (NHC) catalysed carboxylation of aryl boronic acids under one atmospheric pressure of CO2 has been developed. A wide range of aryl boronic acids was transformed into benzoic acid derivatives in moderate to high yields. The carboxylation method shows excellent functional group compatibility, and sensitive functional groups such as carbonyls, esters, and nitriles were tolerated. Mechanistic studies revealed the vital role of the base in promoting the transmetalation step for this copper-catalysed carboxylation.

Graphical abstract: Cu-Catalysed carboxylation of aryl boronic acids with CO2

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Publication details

The article was received on 18 Aug 2019, accepted on 17 Sep 2019 and first published on 23 Sep 2019


Article type: Research Article
DOI: 10.1039/C9QO01023H
Org. Chem. Front., 2019, Advance Article

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    Cu-Catalysed carboxylation of aryl boronic acids with CO2

    O. S. Nayal, J. Hong, Y. Yang and F. Mo, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO01023H

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