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Chiral-at-metal rhodium(iii) complex catalyzed enantioselective synthesis of C2-substituted benzofuran derivatives

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Abstract

A highly efficient enantioselective C2-nucleophilic functionalization of 3-aminobenzofurans with α,β-unsaturated carbonyl compounds has been realized under catalysis of chiral-at-metal rhodium(III) complexes, affording a large array of potentially bioactive C2-substituted benzofuran derivatives with high yields (76–99%) and enantioselectivities (up to 98% ee).

Graphical abstract: Chiral-at-metal rhodium(iii) complex catalyzed enantioselective synthesis of C2-substituted benzofuran derivatives

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Publication details

The article was received on 17 Aug 2019, accepted on 17 Sep 2019 and first published on 18 Sep 2019


Article type: Research Article
DOI: 10.1039/C9QO01022J
Org. Chem. Front., 2019, Advance Article

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    Chiral-at-metal rhodium(III) complex catalyzed enantioselective synthesis of C2-substituted benzofuran derivatives

    H. Zhang, S. Li, Q. Kang and Y. Du, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO01022J

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