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Synthesis of 1-naphthols via Cp*Co(III)-catalyzed C–H activation and cyclization of sulfoxonium ylides with alkynes

Abstract

A highly practical and efficient synthesis of 1-naphthols was developed via Cp*Co(III)-catalyzed C–H activation and cascade [4+2] cyclization between sulfoxonium ylides and alkynes, during which the sulfoxonium ylide functioned as a traceless directing group. This method features operational simplicity, redox-neutral reaction conditions, excellent regioselectivity as well as good substrate compatibility, and various 1-naphthols were efficiently synthesized in 36-92% yields.

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Publication details

The article was received on 12 Aug 2019, accepted on 11 Oct 2019 and first published on 12 Oct 2019


Article type: Research Article
DOI: 10.1039/C9QO00994A
Org. Chem. Front., 2019, Accepted Manuscript

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    Synthesis of 1-naphthols via Cp*Co(III)-catalyzed C–H activation and cyclization of sulfoxonium ylides with alkynes

    Y. Yu, Q. Wu, D. Liu, L. Yu, Z. Tan and G. Zhu, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QO00994A

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