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Access to 2-substituted 1-pyridin-3-yl-β-carboline derivatives by intramolecular radical cyclization-ring opening-SNAr substitution

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Abstract

A new method for the synthesis of 1-pyridin-3-yl-β-carboline derivatives involving an intramolecular radical reaction in the presence of tris(trimethylsilyl)silane and azobisisobutyronitrile (TTMSS/AIBN), via a sultam intermediate, which proceeds as a one-pot process by ring opening and SNAr substitution, is described.

Graphical abstract: Access to 2-substituted 1-pyridin-3-yl-β-carboline derivatives by intramolecular radical cyclization-ring opening-SNAr substitution

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Publication details

The article was received on 26 Jul 2019, accepted on 08 Aug 2019 and first published on 12 Aug 2019


Article type: Research Article
DOI: 10.1039/C9QO00944B
Org. Chem. Front., 2019, Advance Article

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    Access to 2-substituted 1-pyridin-3-yl-β-carboline derivatives by intramolecular radical cyclization-ring opening-SNAr substitution

    J. Recio, A. Pérez-Redondo, J. Alvarez-Builla and C. Burgos, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00944B

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