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Synthesis of α-trifluoromethyl ethanone oximes via the three-component reaction of aryl-substituted ethylenes, tert-butyl nitrite, and the Langlois reagent

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Abstract

A mild and simple protocol for the synthesis of α-trifluoromethylated ethanone oximes from aryl-substituted ethylenes, tert-butyl nitrite, and the Langlois reagent was developed under transition metal-free conditions. In this three-component reaction, tert-butyl nitrite was employed not only as the oxidant but also as the oxime source. A range of α-trifluoromethylated ethanone oximes were obtained, indicating the wide substrate scope of the reaction.

Graphical abstract: Synthesis of α-trifluoromethyl ethanone oximes via the three-component reaction of aryl-substituted ethylenes, tert-butyl nitrite, and the Langlois reagent

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Publication details

The article was received on 25 Jul 2019, accepted on 01 Oct 2019 and first published on 01 Oct 2019


Article type: Research Article
DOI: 10.1039/C9QO00940J
Org. Chem. Front., 2019, Advance Article

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    Synthesis of α-trifluoromethyl ethanone oximes via the three-component reaction of aryl-substituted ethylenes, tert-butyl nitrite, and the Langlois reagent

    K. Lu, X. Wei, Q. Li, Y. Li, L. Ji, E. Hua, Y. Dai and X. Zhao, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00940J

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