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Photocatalyst-free decarboxylative aminoalkylation of imidazo[1,2-a]pyridines with N-aryl glycines enabled by visible light

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Abstract

A novel, green and efficient visible-light-promoted decarboxylative aminoalkylation reaction of imidazo[1,2-a]pyridines with N-aryl glycines has been described. A diverse range of imidazo[1,2-a]pyridines undergoes the reaction well with N-aryl glycines to afford the desired corresponding products in good to high yields. This photocatalyst-free decarboxylative protocol not only manifests high regio-selectivity to biologically important imidazo[1,2-a]pyridines, but also avoids the use of expensive photosensitizers and extra additives, which makes this decarboxylative coupling more practical and sustainable.

Graphical abstract: Photocatalyst-free decarboxylative aminoalkylation of imidazo[1,2-a]pyridines with N-aryl glycines enabled by visible light

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Publication details

The article was received on 23 Jul 2019, accepted on 24 Sep 2019 and first published on 30 Sep 2019


Article type: Research Article
DOI: 10.1039/C9QO00935C
Org. Chem. Front., 2019, Advance Article

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    Photocatalyst-free decarboxylative aminoalkylation of imidazo[1,2-a]pyridines with N-aryl glycines enabled by visible light

    J. Ji, Z. Zhu, L. Xiao, D. Guo, X. Zhu, J. Tang, J. Wu, Z. Xie and Z. Le, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00935C

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