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Oxidant-Controlled Divergent Reactivity of 3-Aminoindazoles

Abstract

An oxidant-controlled divergent reactivity of 3-aminoindazoles is presented herein. Diverse functionalized pyrimido [1,2-b]-indazole derivatives were obtained in good yields via Lewis-acid promoted [3+3] annulation reaction between ketene dithioacetals and 3-aminoindazoles. When the reaction was performed with the Cu/[O] catalytic system, a new reactivity for ring-opening of 3-aminoindazoles via the C-N bond activation was achieved, which enables the olefinic C-H arylation of ketene dithioacetals under mild conditions.

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Publication details

The article was received on 03 Jul 2019, accepted on 09 Aug 2019 and first published on 09 Aug 2019


Article type: Research Article
DOI: 10.1039/C9QO00847K
Org. Chem. Front., 2019, Accepted Manuscript

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    Oxidant-Controlled Divergent Reactivity of 3-Aminoindazoles

    Y. Zhou, Y. Lou, Y. Wang and Q. Song, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QO00847K

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