Jump to main content
Jump to site search

Issue 18, 2019
Previous Article Next Article

Canescones A–E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens

Author affiliations

Abstract

Three pairs of enantiomers (±)-canescones A–C (1–3), along with a pair of stereoisomers canescones D (4) and E (5), aromatic polyketide dimers bearing unprecedented 5/6/6/6/5 heterocyclic chemical architectures with a rare pentacyclic dihydrobenzo[1,4]dioxine core, were isolated from the fungus Penicillium canescens. Structure elucidation unambiguously suggests that 1 and 2 feature a new cyclopentanone ring A rather than a pyrrolidinone or furanone ring present in 3–5. All compounds were assayed for PTP1B inhibitory activity, and their hypothetical biosynthetic pathways were proposed.

Graphical abstract: Canescones A–E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Jun 2019, accepted on 30 Jul 2019 and first published on 06 Aug 2019


Article type: Research Article
DOI: 10.1039/C9QO00820A
Org. Chem. Front., 2019,6, 3274-3281

  •   Request permissions

    Canescones A–E: aromatic polyketide dimers with PTP1B inhibitory activity from Penicillium canescens

    Y. Zang, Y. Gong, X. Li, X. Li, J. Liu, C. Chen, Y. Zhou, L. Gu, Z. Luo, J. Wang, W. Sun, H. Zhu and Y. Zhang, Org. Chem. Front., 2019, 6, 3274
    DOI: 10.1039/C9QO00820A

Search articles by author

Spotlight

Advertisements