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C(sp3)–H hydroxylation of fluorenes, oxindoles and benzofuranones with a Mg(NO3)2–HP(O)Ph2 oxidation system

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Abstract

A novel oxidation system in which magnesium nitrate [Mg(NO3)2] is used as an oxidant in the presence of diphenylphosphine oxide [HP(O)Ph2] permits the C(sp3)–H hydroxylation of fluorenes, oxindoles, and benzofuranones. This method features high efficiency, good functional group tolerance, and operational simplicity. Its synthetic utility is highlighted by further transformations to valuable organic materials.

Graphical abstract: C(sp3)–H hydroxylation of fluorenes, oxindoles and benzofuranones with a Mg(NO3)2–HP(O)Ph2 oxidation system

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Publication details

The article was received on 18 Jun 2019, accepted on 16 Jul 2019 and first published on 19 Jul 2019


Article type: Research Article
DOI: 10.1039/C9QO00778D
Org. Chem. Front., 2019, Advance Article

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    C(sp3)–H hydroxylation of fluorenes, oxindoles and benzofuranones with a Mg(NO3)2–HP(O)Ph2 oxidation system

    C. Hu, G. Hong, P. D. Nahide, Y. He, C. Zhou, M. C. Kozlowski and L. Wang, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00778D

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