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Issue 17, 2019
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Copper catalysis for highly selective aerobic oxidation of alcohols to aldehydes/ketones

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Abstract

Oxidation of alcohols to aldehydes/ketones is a transformation of fundamental importance. Usually stoichiometric amounts of oxidants are required for these types of reactions. Although aerobic oxidations have been studied, there exist challenges: complicated additives, toxic or expensive catalyst(s), a large amount of base or molecular sieves, limited substrate scope, isomerization of Z C[double bond, length as m-dash]C bonds, etc. Herein, a general and practical room temperature aerobic oxidation of different types of alcohols including allenols, alkenols, propargylic alcohols, benzylic alcohols, and aliphatic alcohols in MeCN (acetonitrile) or DCE (1,2-dichloroethane) using readily available and cheap Cu(NO3)2·3H2O and TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) or 4-HO-TEMPO as the catalysts forming aldehydes or ketones with an excellent selectivity has been developed. Some thirty to forty mmol scale reactions have been demonstrated.

Graphical abstract: Copper catalysis for highly selective aerobic oxidation of alcohols to aldehydes/ketones

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Publication details

The article was received on 07 Jun 2019, accepted on 08 Jul 2019 and first published on 10 Jul 2019


Article type: Research Article
DOI: 10.1039/C9QO00740G
Org. Chem. Front., 2019,6, 3101-3106

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    Copper catalysis for highly selective aerobic oxidation of alcohols to aldehydes/ketones

    D. Zhai and S. Ma, Org. Chem. Front., 2019, 6, 3101
    DOI: 10.1039/C9QO00740G

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