Issue 19, 2019
From the journal:

Organic Chemistry Frontiers

Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms†

Cai-Feng Ding,‡ae   Rong-Ping Zhang,‡d   Hao-Fei Yu,bd   Jing Yang,a   Xu-Jie Qin,a   Zhi Dai,a   Ya-Ping Liu,a   Qiu-Min Lu,c   Ren Lai*c  and  Xiao-Dong Luo ORCID logo *ab  

* Corresponding authors

a Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China
E-mail: xdluo@mail.kib.ac.cn

b Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, People's Republic of China

c Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming 650223, People's Republic of China
E-mail: rlai@mail.kiz.ac.cn

d School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, People's Republic of China

e Graduate University of the Chinese Academy of Sciences, Beijing 100049, People's Republic of China

Abstract

Thalfoetines A–D (1–4), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C–C bond linking two building blocks, were isolated from Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria significantly, and compound 1 damaged the cell structure of Staphylococcus aureus and inhibited its DNA synthesis.

Graphical abstract: Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms

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Article information

DOI
https://doi.org/10.1039/C9QO00737G
Article type
Research Article
Submitted
06 Jun 2019
Accepted
05 Aug 2019
First published
29 Aug 2019

Org. Chem. Front., 2019,6, 3428-3434

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Hybrid isoquinolines from Thalictrum foetidum: a new type of aporphine inhibiting Staphylococcus aureus by combined mechanisms

C. Ding, R. Zhang, H. Yu, J. Yang, X. Qin, Z. Dai, Y. Liu, Q. Lu, R. Lai and X. Luo, Org. Chem. Front., 2019, 6, 3428 DOI: 10.1039/C9QO00737G

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