Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.



Electrochemical Minisci-type trifluoromethylation of electron-deficient heterocycles mediated by bromide ion

Abstract

An electrochemical methodology for the Minisci-type trifluoromethylation of electron-deficient heterocycles mediated by cheap and easily available bromide ion has been developed. By virtue of the in situ generated sulfonyl hypobromite in-termediate, the CF3 radical can be regulated and controlled at a low concentration, thereby improving the reaction efficiency over the direct electrolysis. Also, this indirect electrochemical process is performed in a beaker-type undivided cell under galvanostatic conditions, without using external expensive supporting electrolytes. This protocol provides an alternative electrochemical trifluoromethylation methodology for the late-stage functionalization of biologically important molecules.

Back to tab navigation

Supplementary files

Publication details

The article was received on 25 Apr 2019, accepted on 14 May 2019 and first published on 15 May 2019


Article type: Research Article
DOI: 10.1039/C9QO00552H
Org. Chem. Front., 2019, Accepted Manuscript

  •   Request permissions

    Electrochemical Minisci-type trifluoromethylation of electron-deficient heterocycles mediated by bromide ion

    G. dou, Y. Jiang, K. Xu and C. Zeng, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QO00552H

Search articles by author

Spotlight

Advertisements