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Issue 14, 2019
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Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3H)-quinazolinones

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Abstract

Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3H)-quinazolinones with α-diazotized Meldrum's acid has been achieved successfully via a metal carbene migratory insertion process. With a Cp*Rh(III) catalyst, monoalkylation compounds are the predominant products while a Cp*Ir(III) catalyst selectively affords dialkylation products. Furthermore, these developed methods have good functional group tolerance with a low catalyst loading unprecedentedly.

Graphical abstract: Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3H)-quinazolinones

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Publication details

The article was received on 09 Apr 2019, accepted on 08 May 2019 and first published on 08 May 2019


Article type: Research Article
DOI: 10.1039/C9QO00496C
Org. Chem. Front., 2019,6, 2348-2352

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    Catalyst-controlled selective mono-/dialkylation of 2-aryl-4(3H)-quinazolinones

    Y. Luo, H. He, J. Li, X. Yu, M. Guan and Y. Wu, Org. Chem. Front., 2019, 6, 2348
    DOI: 10.1039/C9QO00496C

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