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Organic Photoredox Catalytic Decarboxylative Cross-Coupling of gem-Difluoroalkenes with Unactivated Carboxylic Acids

Abstract

The monofluoroalkene substructure plays a crucial role in various fields of organic synthesis, pharmacology and materials science. However, a redox-neutral direct monofluoroalkenylation of prevalent alkyl sources still remains very challenging. Herein, the first monofluoroalkenylation of naturally abundant unactivated carboxylic acids via organic photoredox catalytic decarboxylation has been developed. This redox-neutral approach avoides the utilization of presynthesized redox-active esters and high energy irradiation, providing a mild and efficient strategy for direct decarboxylative cross-coupling reactions of unactivated carboxylic acids. Furthermore, it allows the remarkably and challenging late-stage monofluoroalkenylation of complex molecular architectures such as bioactive Ramipril, Gemfibrozil, dehydroabietic acid, enoxolone and saccharide-derived cyclic α-oxy acid.

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Publication details

The article was received on 09 Apr 2019, accepted on 08 May 2019 and first published on 10 May 2019


Article type: Research Article
DOI: 10.1039/C9QO00495E
Org. Chem. Front., 2019, Accepted Manuscript

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    Organic Photoredox Catalytic Decarboxylative Cross-Coupling of gem-Difluoroalkenes with Unactivated Carboxylic Acids

    H. Yang, C. Tian, D. Qiu, H. Tian, G. An and G. Li, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QO00495E

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