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Cobalt catalyzed regioselective C–H methylation/acetoxylation of anilides: new routes for C–C and C–O bond formation

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Abstract

The first cobalt-catalyzed regioselective C–H methylation/acetoxylation reactions of anilides using peroxides and acetic acid respectively as attacking reagents have been developed herein. This new strategy features low cost, high selectivity, a broad range of functional groups, use of green and low toxic DTBP and HOAc, and avoidance of extraneous directing groups, thus offering a good complement to previous C–H methylation/acetoxylation reactions and expanding the application of cobalt-catalyzed C–H activations. Mechanistic explorations into the reaction process are also described in detail.

Graphical abstract: Cobalt catalyzed regioselective C–H methylation/acetoxylation of anilides: new routes for C–C and C–O bond formation

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Publication details

The article was received on 22 Mar 2019, accepted on 30 Apr 2019 and first published on 30 Apr 2019


Article type: Research Article
DOI: 10.1039/C9QO00411D
Org. Chem. Front., 2019, Advance Article

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    Cobalt catalyzed regioselective C–H methylation/acetoxylation of anilides: new routes for C–C and C–O bond formation

    Z. Li, P. Wu and C. Cai, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00411D

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