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Oxidation of Amine α-Carbon to Amide: A Review on Direct Method to Access the Amide Functionality

Abstract

A number of methods are adopted for synthesis of amides; among the amides synthesis methods oxidation of amines to amide is growing the interest to prepare this imperative functional group. Amine group possessing α-CH, α-CH2, and α-CH3 at the α-position have been utilized in the oxidation reactions to give its corresponding amides. Amides in turn have been used in the oxidation reactions to prepare imides. This review covers the literature relating to the construction of the amide bond formation from amines using transition metal-based oxidants, non-metal based oxidants and the key areas of molecular oxygen has been utilized for an oxidant in the presence of catalysts. The use of molecular oxygen in the metal/non-metal catalyzed oxidation of amines has led to the development of a powerful methodology for amide bond formation.

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Publication details

The article was received on 17 Mar 2019, accepted on 15 May 2019 and first published on 17 May 2019


Article type: Review Article
DOI: 10.1039/C9QO00387H
Org. Chem. Front., 2019, Accepted Manuscript

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    Oxidation of Amine α-Carbon to Amide: A Review on Direct Method to Access the Amide Functionality

    N. Paramathevar and V. K. V, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QO00387H

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