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A AgOAc/quinine-derived aminophosphine complex as an efficient catalyst for diastereo- and enantioselective 1,3-dipolar cycloaddition of α,β-unsaturated 7-azaindoline amides and azomethine ylides

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Abstract

A quinine-derived aminophosphine/Ag(I) complex was firstly demonstrated to be an efficient catalyst for the highly stereoselective 1,3-dipolar cycloaddition of azomethine ylides with challenging α,β-unsaturated amide substrates. A wide range of densely functionalized pyrrolidine derivatives containing four contiguous stereogenic centers could be smoothly obtained with excellent diastereo- and enantioselectivities.

Graphical abstract: A AgOAc/quinine-derived aminophosphine complex as an efficient catalyst for diastereo- and enantioselective 1,3-dipolar cycloaddition of α,β-unsaturated 7-azaindoline amides and azomethine ylides

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Publication details

The article was received on 08 Mar 2019, accepted on 12 Apr 2019 and first published on 15 Apr 2019


Article type: Research Article
DOI: 10.1039/C9QO00347A
Org. Chem. Front., 2019, Advance Article

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    A AgOAc/quinine-derived aminophosphine complex as an efficient catalyst for diastereo- and enantioselective 1,3-dipolar cycloaddition of α,β-unsaturated 7-azaindoline amides and azomethine ylides

    Y. Zhang, Y. You, J. Zhao, X. Zhou, X. Zhang, X. Xu and W. Yuan, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00347A

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