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AgOAc/Quinine-Derived Aminophosphine Complex as Efficient Catalyst for Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of α,β-Unsaturated 7-Azaindoline Amides and Azomethine Ylides

Abstract

A quinine-derived aminophosphine/Ag(I) complex was firstly demonstrated to be an efficient catalyst for the highly stereoselective 1,3-dipolar cycloaddition of azomethine ylides with challenging substrates α,β-unsaturated amides. A wide range of densely functionalized pyrrolidine derivatives containing four contiguous stereogenic centers could be smoothly obtained in excellent diastereo- and enantioselectivities.

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Publication details

The article was received on 08 Mar 2019, accepted on 12 Apr 2019 and first published on 15 Apr 2019


Article type: Research Article
DOI: 10.1039/C9QO00347A
Citation: Org. Chem. Front., 2019, Accepted Manuscript

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    AgOAc/Quinine-Derived Aminophosphine Complex as Efficient Catalyst for Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of α,β-Unsaturated 7-Azaindoline Amides and Azomethine Ylides

    Y. Zhang, Y. You, J. Zhao, X. Zhou, X. Zhang, X. Xu and W. Yuan, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QO00347A

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