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Catalyst free amination of α-cyano arylacetates enabled by single-electron transfer

Abstract

A radical benzylic amination of α-cyano arylacetates without the assistance of any transition-metal catalysts or external photosensitizers was realized. This protocol is operationally simple, mild and high efficiency. The products could be easily transformed to useful vicinal diamines and α-amino amides. DFT calculations revealed the origin of benzylic rather than aromatic amination regioselectivity in the present reaction.

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Publication details

The article was received on 08 Mar 2019, accepted on 12 Apr 2019 and first published on 16 Apr 2019


Article type: Research Article
DOI: 10.1039/C9QO00346K
Citation: Org. Chem. Front., 2019, Accepted Manuscript

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    Catalyst free amination of α-cyano arylacetates enabled by single-electron transfer

    W. Zhang, H. Zhen, Y. Liu, A. Yu, C. Yang, X. Li and J. Cheng, Org. Chem. Front., 2019, Accepted Manuscript , DOI: 10.1039/C9QO00346K

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