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Copper-catalyzed direct couplings of terminal alkynes with primary and secondary benzyl bromides

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Abstract

We have developed a facile Cu-catalyzed benzylation of terminal alkynes from easily available benzyl bromides. Both primary and secondary benzylic bromides have been successfully coupled with various aryl alkynes, alkyl alkynes and enynes, selectively affording benzyl alkynes in moderate to excellent yields. Examples of scale-up reactions as well as the application for preparing substituted allenes and phenanthrene have further demonstrated the practicality and efficiency of the developed strategy.

Graphical abstract: Copper-catalyzed direct couplings of terminal alkynes with primary and secondary benzyl bromides

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Publication details

The article was received on 06 Mar 2019, accepted on 19 Apr 2019 and first published on 19 Apr 2019


Article type: Research Article
DOI: 10.1039/C9QO00335E
Org. Chem. Front., 2019, Advance Article

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    Copper-catalyzed direct couplings of terminal alkynes with primary and secondary benzyl bromides

    H. Zhang, N. Sun, B. Hu, Z. Shen, X. Hu and L. Jin, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00335E

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