Jump to main content
Jump to site search


Palladium-catalyzed dearomative arylphosphorylation of indoles

Author affiliations

Abstract

A palladium-catalyzed dearomative arylphosphorylation reaction of indoles involving C–C/C–P bond formation is developed. Through the intramolecular dearomative carbopalladation of indoles followed by an intermolecular benzyl–Pd termination with dialkylphosphite, a range of unique indolines bearing vicinal tetrasubstituted and phosphate-containing trisubstituted stereocenters are obtained in good yields. Synthetic transformations of the product show practical utilities of the reaction.

Graphical abstract: Palladium-catalyzed dearomative arylphosphorylation of indoles

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Feb 2019, accepted on 23 Mar 2019 and first published on 27 Mar 2019


Article type: Research Article
DOI: 10.1039/C9QO00246D
Citation: Org. Chem. Front., 2019, Advance Article

  •   Request permissions

    Palladium-catalyzed dearomative arylphosphorylation of indoles

    J. Weng, L. Xing, W. Hou, R. Liang and Y. Jia, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00246D

Search articles by author

Spotlight

Advertisements