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Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole-pyrrolidine]s through organocatalytic cycloaddition

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Abstract

A series of compounds featuring novel bispiro[benzofuran-oxindole-pyrrolidine] moieties have been achieved through a thiourea-catalyzed 1,3-dipolar cycloaddition reaction. The Michael/Mannich reaction of N-2,2,2-trifluoroethylisatin ketimines with aurones furnished the cycloadducts in excellent yields with excellent stereoselectivities.

Graphical abstract: Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole-pyrrolidine]s through organocatalytic cycloaddition

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Publication details

The article was received on 13 Feb 2019, accepted on 17 Mar 2019 and first published on 18 Mar 2019


Article type: Research Article
DOI: 10.1039/C9QO00241C
Citation: Org. Chem. Front., 2019, Advance Article

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    Highly efficient enantioselective synthesis of bispiro[benzofuran-oxindole-pyrrolidine]s through organocatalytic cycloaddition

    B. Li, F. Gao, X. Feng, M. Sun, Y. Guo, D. Wen, Y. Deng, J. Huang, K. Wang and W. Yan, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00241C

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