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Visible-light-mediated hydrodehalogenation and Br/D exchange of inactivated aryl and alkyl halides with a palladium complex

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Abstract

Herein, a novel photo-induced amine-free radical reductive dehalogenation of inactivated aryl/alkyl bromides and chlorides with a palladium complex is described, which reveals excellent functional group compatibility and broad substrate scope. Extensional transformations for reductive cyclization, dehalogenative deuteration, and intra- and intermolecular radical addition can be achieved smoothly. Mechanistic studies indicate a single-electron photoredox catalytic system with inactivated solvent as the hydrogen atom donor.

Graphical abstract: Visible-light-mediated hydrodehalogenation and Br/D exchange of inactivated aryl and alkyl halides with a palladium complex

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Publication details

The article was received on 13 Feb 2019, accepted on 27 Mar 2019 and first published on 28 Mar 2019


Article type: Research Article
DOI: 10.1039/C9QO00240E
Citation: Org. Chem. Front., 2019, Advance Article

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    Visible-light-mediated hydrodehalogenation and Br/D exchange of inactivated aryl and alkyl halides with a palladium complex

    Z. Zhou, J. Zhao, X. Gou, X. Chen and Y. Liang, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00240E

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