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Issue 9, 2019
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Pd(II)/Ag(I)-Cocatalyzed ortho direct arylation of O-phenylcarbamates with pinacol aryl boronates

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Abstract

Ortho direct arylation of O-phenylcarbamates using aryl boronates as coupling partners has been realized for the first time in the literature. A mechanistic investigation showed that the Wheland intermediate with ortho C–H remaining after carbopalladation was the key intermediate for further transformation. Isotope competition experiments indicated that C–H cleavage was not involved in the rate-determining step.

Graphical abstract: Pd(ii)/Ag(i)-Cocatalyzed ortho direct arylation of O-phenylcarbamates with pinacol aryl boronates

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Publication details

The article was received on 12 Feb 2019, accepted on 04 Mar 2019 and first published on 05 Mar 2019


Article type: Research Article
DOI: 10.1039/C9QO00227H
Citation: Org. Chem. Front., 2019,6, 1409-1413

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    Pd(II)/Ag(I)-Cocatalyzed ortho direct arylation of O-phenylcarbamates with pinacol aryl boronates

    H. Ma, T. Wang, C. Gao, G. Li, M. Zhang and Q. Wang, Org. Chem. Front., 2019, 6, 1409
    DOI: 10.1039/C9QO00227H

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