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Issue 10, 2019
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Littordials A–E, novel formyl-phloroglucinol-β-caryophyllene meroterpenoids from the leaves of Psidium littorale

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Abstract

Five novel formyl-phloroglucinol-β-caryophyllene meroterpenoids, namely littordials A–E (1–5), were isolated from the leaves of Psidium littorale. Their structures were established by spectroscopic data and computational methods, and the structure of 1 was confirmed by X-ray crystallography. Littordials A–E feature unusual acyl phloroglucinol units, and 5 possesses a rare 6/7/9/4-fused tetracyclic ring system. Compounds 2, 3 and 5 exhibited cytotoxic activities on two cancer cell lines (MDA-MB-231 and B16) with IC50 values from 6.6 ± 1.5 to 9.2 ± 1.7 μM.

Graphical abstract: Littordials A–E, novel formyl-phloroglucinol-β-caryophyllene meroterpenoids from the leaves of Psidium littorale

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Article information


Submitted
02 Feb 2019
Accepted
25 Mar 2019
First published
26 Mar 2019

Org. Chem. Front., 2019,6, 1667-1673
Article type
Research Article

Littordials A–E, novel formyl-phloroglucinol-β-caryophyllene meroterpenoids from the leaves of Psidium littorale

J. Xu, H. Zhu, J. Zhang, W. Liu, J. Luo, K. Pan, W. Cao, Q. Bi, F. Feng and W. Qu, Org. Chem. Front., 2019, 6, 1667
DOI: 10.1039/C9QO00174C

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