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Issue 7, 2019
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Temperature-induced large amplitude conformational change in the complex of oxatub[4]arene revealed via rotaxane synthesis

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Abstract

Elevated temperature usually plays a destructive role in supramolecular complexes. At higher temperature, folded proteins tend to unfold and supramolecular assemblies tend to disassemble. In contrast, histidine kinases are able to perform a different function at higher temperature. This results from temperature-induced large amplitude conformational changes. However, similar phenomena have rarely been reported for synthetic receptors. Herein, we report that the conformationally adaptive oxatub[4]arene is able to show a conformational response to temperature change in the presence of an appropriate guest. By employing rotaxane synthesis, the host's conformation in the complex at different temperatures can be fixed. The resulting rotaxanes with different host conformations have been carefully characterized by using 2D NMR spectroscopy, mass spectrometry, and X-ray single crystallography.

Graphical abstract: Temperature-induced large amplitude conformational change in the complex of oxatub[4]arene revealed via rotaxane synthesis

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Publication details

The article was received on 30 Jan 2019, accepted on 19 Feb 2019 and first published on 21 Feb 2019


Article type: Research Article
DOI: 10.1039/C9QO00159J
Org. Chem. Front., 2019,6, 1027-1031

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    Temperature-induced large amplitude conformational change in the complex of oxatub[4]arene revealed via rotaxane synthesis

    D. Li, L. Yang, H. Chai, F. Jia, H. Ke and W. Jiang, Org. Chem. Front., 2019, 6, 1027
    DOI: 10.1039/C9QO00159J

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