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Palladium/copper-catalyzed decarbonylative heteroarylation of amides via C–N bond activation

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Abstract

A novel strategy for the synthesis of 2-arylated oxazole derivatives via palladium/copper-catalyzed decarbonylative heteroarylation of amides via C–N bond activation by ground-state destabilization is reported. This transformation shows good functional group tolerance and delivers the versatile 2-arylated oxazole derivatives in moderate to good yields. This transformation provides unique and efficient strategies for converting readily available amides and the precursor carboxylic acids into valuable chemicals.

Graphical abstract: Palladium/copper-catalyzed decarbonylative heteroarylation of amides via C–N bond activation

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Publication details

The article was received on 25 Jan 2019, accepted on 22 Feb 2019 and first published on 22 Feb 2019


Article type: Research Article
DOI: 10.1039/C9QO00106A
Citation: Org. Chem. Front., 2019, Advance Article

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    Palladium/copper-catalyzed decarbonylative heteroarylation of amides via C–N bond activation

    P. Zhou, S. Shi, J. Wang, Y. Zhang, C. Li and C. Ge, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00106A

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