Palladium/copper-catalyzed decarbonylative heteroarylation of amides via C–N bond activation

Abstract

A novel strategy for the synthesis of 2-arylated oxazole derivatives via palladium/copper-catalyzed decarbonylative heteroarylation of amides via C–N bond activation by ground-state destabilization is reported. This transformation shows good functional group tolerance and delivers the versatile 2-arylated oxazole derivatives in moderate to good yields. This transformation provides unique and efficient strategies for converting readily available amides and the precursor carboxylic acids into valuable chemicals.