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Facile synthesis of 2-(2-aminobenzoyl)benzoic acids via a base-promoted aerobic cascade reaction

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Abstract

A novel strategy for the regiospecific synthesis of 2-(2-aminobenzoyl)benzoic acids via a base-promoted aerobic cascade reaction has been exploited. The protocol led to a wide panel of 2-(2-aminobenzoyl)benzoic acids with a broad substrate scope in an atom-economical manner. Six new bonds were sequentially formed in this one-pot procedure.

Graphical abstract: Facile synthesis of 2-(2-aminobenzoyl)benzoic acids via a base-promoted aerobic cascade reaction

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Publication details

The article was received on 23 Jan 2019, accepted on 04 Mar 2019 and first published on 05 Mar 2019


Article type: Research Article
DOI: 10.1039/C9QO00101H
Citation: Org. Chem. Front., 2019, Advance Article

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    Facile synthesis of 2-(2-aminobenzoyl)benzoic acids via a base-promoted aerobic cascade reaction

    J. Shen, Y. Chen, T. Chen, Z. Zou, Y. Feng and Q. You, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C9QO00101H

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