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Issue 9, 2019
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Copper-catalyzed one-pot three-component thioamination of 1,4-naphthoquinone

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Abstract

A concise one-pot three-component thioamination of 1,4-naphthoquinone with thiols and amines was developed to synthesize 2-amino-3-thio-1,4-naphthoquinones. The approach employed CuI as the catalyst and ambient O2 as the green oxidant, giving a series of thioaminated 1,4-naphthoquinones in moderate to good yields. This catalytic approach represents a step-economic and convenient strategy for the difunctionalization of 1,4-naphthoquinones.

Graphical abstract: Copper-catalyzed one-pot three-component thioamination of 1,4-naphthoquinone

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Publication details

The article was received on 20 Jan 2019, accepted on 14 Mar 2019 and first published on 15 Mar 2019


Article type: Research Article
DOI: 10.1039/C9QO00091G
Citation: Org. Chem. Front., 2019,6, 1476-1480

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    Copper-catalyzed one-pot three-component thioamination of 1,4-naphthoquinone

    F. Zeng, X. Chen, S. He, K. Sun, Y. Liu, R. Fu, L. Qu, Y. Zhao and B. Yu, Org. Chem. Front., 2019, 6, 1476
    DOI: 10.1039/C9QO00091G

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