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Issue 7, 2019
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Biomimetic folding of small organic molecules driven by multiple non-covalent interactions

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Abstract

Here we report our research on biomimetic folding architectures self-assembled hierarchically from well-designed UPy-based monomers with low molecular weight (MW < 400 Da). These monomers are first dimerized via quadruple hydrogen bonding and then form folded dimers with the assistance of π–π interactions. More interestingly, the folded dimer further formed one-dimensional supramolecular stacks through additional weak π–π interactions in the solid state. Similar to DNA, these well-defined structures are stabilized by the concerted hydrogen bonding and π–π interaction in a synergistic manner, which would provide inspiration for constructing biomimetic self-folding materials.

Graphical abstract: Biomimetic folding of small organic molecules driven by multiple non-covalent interactions

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Publication details

The article was received on 20 Jan 2019, accepted on 08 Feb 2019 and first published on 12 Feb 2019


Article type: Research Article
DOI: 10.1039/C9QO00089E
Citation: Org. Chem. Front., 2019,6, 936-941

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    Biomimetic folding of small organic molecules driven by multiple non-covalent interactions

    T. Xiao, L. Xu, J. Wang, Z. Li, X. Sun and L. Wang, Org. Chem. Front., 2019, 6, 936
    DOI: 10.1039/C9QO00089E

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