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Issue 8, 2019
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Expedient synthesis of a symmetric cycloheptyne-Co2(CO)6 complex for orthogonal Huisgen cycloadditions

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Abstract

A short procedure to prepare a cycloheptyne di-cobalt-carbonyl complex functionalised by a terminal alkyne is reported. This symmetric complex can react selectively in Strain Promoted Alkyne Azide Cycloaddition (SPAAC) or Copper Catalysed Alkyne Azide Cycloaddition (CuAAC) depending on the conditions, providing a new and practical tool for orthogonal conjugation reactions with azido reagents.

Graphical abstract: Expedient synthesis of a symmetric cycloheptyne-Co2(CO)6 complex for orthogonal Huisgen cycloadditions

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Article information


Submitted
18 Jan 2019
Accepted
21 Feb 2019
First published
28 Feb 2019

Org. Chem. Front., 2019,6, 1114-1117
Article type
Research Article

Expedient synthesis of a symmetric cycloheptyne-Co2(CO)6 complex for orthogonal Huisgen cycloadditions

M. Cormier, E. Fouquet and P. Hermange, Org. Chem. Front., 2019, 6, 1114
DOI: 10.1039/C9QO00086K

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