Catalyst-free oxidative N–N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO

Yue-Ming Cai; Xin Zhang; Cui An; Ye-Fei Yang; Wei Liu; Wen-Xia Gao; Xiao-Bo Huang; Yun-Bing Zhou; Miao-Chang Liu; Hua-Yue Wu

doi:10.1039/C9QO00071B

Catalyst-free oxidative N–N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO†

Yue-Ming Cai,^a Xin Zhang,^a Cui An,^a Ye-Fei Yang,^a Wei Liu,^a Wen-Xia Gao,

^a Xiao-Bo Huang,

^a Yun-Bing Zhou,*^a Miao-Chang Liu

*^a and Hua-Yue Wu

^a

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* Corresponding authors

^a College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou, P. R. of China
E-mail: zyb@wzu.edu.cn, mcl@wzu.edu.cn

Abstract

We disclose a catalyst-free method to synthesize 1,2,3-triazoles rapidly via an oxidative N–N coupling strategy. Of particular note is that the one-step synthesis route to access [1,2,3]triazolo[1,5-a]pyridines from pyridin-2-ylmethanamine has been reported for the first time. This approach features no use of catalyst, extremely mild conditions and excellent efficiency.

Organic Chemistry Frontiers

Catalyst-free oxidative N–N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO†

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Catalyst-free oxidative N–N coupling for the synthesis of 1,2,3-triazole compounds with tBuONO

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