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Issue 7, 2019
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Highly efficient copper-catalyzed direct C–H amidation of quinoxalin-2(1H)-ones with amidates under microwave irradiation

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Abstract

A novel and highly efficient copper-catalyzed direct oxidative amidation of quinoxalin-2(1H)-ones with a variety of aromatic and aliphatic amides was described. This methodology provided a practical approach to various 3-acylamino quinoxalin-2(1H)-ones from readily available starting materials in good to excellent yields.

Graphical abstract: Highly efficient copper-catalyzed direct C–H amidation of quinoxalin-2(1H)-ones with amidates under microwave irradiation

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Publication details

The article was received on 15 Jan 2019, accepted on 08 Feb 2019 and first published on 12 Feb 2019


Article type: Research Article
DOI: 10.1039/C9QO00063A
Citation: Org. Chem. Front., 2019,6, 925-935

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    Highly efficient copper-catalyzed direct C–H amidation of quinoxalin-2(1H)-ones with amidates under microwave irradiation

    J. Yuan, J. Zhu, J. Fu, L. Yang, Y. Xiao, P. Mao, X. Du and L. Qu, Org. Chem. Front., 2019, 6, 925
    DOI: 10.1039/C9QO00063A

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