Jump to main content
Jump to site search


One-pot, three-component approach to diarylacetonitriles

Author affiliations

Abstract

Described herein is a novel one-pot, three-component reaction where aldehydes, electron-rich arenes, and TMSCN in the presence of BF3-OEt2 allowed direct access to a number of diarylacetonitriles under mild reaction conditions in good to excellent yields. Implementation of this assembly protocol to a concise synthetic approach to shoreaphenol, a bioactive oligostilbenoid natural product, is also demonstrated.

Graphical abstract: One-pot, three-component approach to diarylacetonitriles

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Dec 2018, accepted on 18 Jan 2019 and first published on 18 Jan 2019


Article type: Research Article
DOI: 10.1039/C8QO01419A
Citation: Org. Chem. Front., 2019, Advance Article

  •   Request permissions

    One-pot, three-component approach to diarylacetonitriles

    D. K. Singh, S. S. Prasad, J. Kim and I. Kim, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01419A

Search articles by author

Spotlight

Advertisements