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Manganese-mediated reductive amidation of esters with nitroarenes

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Abstract

Amides are ubiquitous molecules in nature and in synthetic chemistry. Here we report a convenient and efficient method to synthesize N-aryl amides via amidation of esters with nitroarenes. In the presence of manganese metal, this amidation proceeded smoothly without the need for additional catalysts or ligands. Various esters and nitroarenes are suitable substrates to afford a wide range of N-aryl amides, including bio-active molecules and intermediates to drug molecules.

Graphical abstract: Manganese-mediated reductive amidation of esters with nitroarenes

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Publication details

The article was received on 25 Dec 2018, accepted on 28 Jan 2019 and first published on 30 Jan 2019


Article type: Research Article
DOI: 10.1039/C8QO01405A
Citation: Org. Chem. Front., 2019, Advance Article

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    Manganese-mediated reductive amidation of esters with nitroarenes

    C. W. Cheung, N. Shen, S. Wang, A. Ullah, X. Hu and J. Ma, Org. Chem. Front., 2019, Advance Article , DOI: 10.1039/C8QO01405A

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